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A new interaction between BRCA2 and DDX5 promotes the repair of DNA breaks at transcribed chromatin.

Belén Gómez-GonzálezGaetana SessaAura CarreiraAndrés Aguilera
Published in: Molecular & cellular oncology (2021)
In a recent report, we have revealed a new interaction between the BRCA2 DNA repair associated protein (BRCA2) and the DEAD-box helicase 5 (DDX5) at DNA breaks that promotes unwinding DNA-RNA hybrids within transcribed chromatin and favors repair. Interestingly, BRCA2-DDX5 interaction is impaired in cells expressing the BRCA2T2 07A missense variant found in breast cancer patients.
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