Plasma Protein Profiling of Incident Cardiovascular Diseases: A Multisample Evaluation.
Lars LindOlga E TitovaRui ZhengDaniela ZanettiMartin IngelssonStefan GustafssonJohan SundströmJohan ÄrnlövSölve ElmståhlThemistocles L AssimesKarl MichaëlssonPublished in: Circulation. Genomic and precision medicine (2023)
Protein profiling in multiple samples disclosed several new proteins to be associated with subsequent myocardial infarction, stroke, and heart failure, suggesting common pathophysiological pathways for these diseases. KIM-1, urokinase plasminogen activator surface receptor, and adrenomedullin were novel early markers of CVD. A selection of 11 proteins improved the discrimination of CVD.