LUF7244, an allosteric modulator/activator of Kv 11.1 channels, counteracts dofetilide-induced torsades de pointes arrhythmia in the chronic atrioventricular block dog model.
Muge QileHenriette D M BeekmanDavid J SprenkelerMarien J C HoutmanWillem B van HamAnna Stary-WeinzingerStanislav BeylSteffen HeringDirk-Jan van den BergElizabeth C M de LangeLaura H HeitmanAd P IJzermanMarc A VosMarcel A G van der HeydenPublished in: British journal of pharmacology (2019)
LUF7244 counteracted dofetilide-induced early afterdepolarizations in vitro and torsades de pointes in vivo. Allosteric modulators/activators of Kv 11.1 channels might neutralize adverse cardiac effects of existing drugs and newly developed compounds that display QTc lengthening.