Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors.

Angelo SparaneoFederico Pio FabrizioAnnamaria la TorrePaolo GrazianoMassimo Di MaioAndrea FontanaMichele BiscegliaAntonio RossiStefano PizzolittoGiovanna De MaglioAntonio TancrediFranco GrimaldiTeresa BalsamoFlavia CentraMaria Carmina ManzorraDomenico TrombettaAngela PantaloneAntonio BonfittoEvaristo MaielloVito Michele FazioLucia Anna Muscarella

Published in: International journal of molecular sciences (2019)

This is the first study that has described the effects of KEAP1 silencing on the regulation of NRF2 activity in lung carcinoids cells. The epigenetic deregulation of the KEAP1/NRF2 by a KEAP1 promoter hypermethylation system appears to be a frequent event in lung carcinoids.

Keyphrases

oxidative stress
protein protein
dna methylation
induced apoptosis
gene expression
small molecule
transcription factor
cell proliferation
cell death