CF 3 SO 2 Na-Mediated Visible-Light-Induced Cross-Dehydrogenative Coupling of Heteroarenes with Aliphatic C(sp 3 )-H Bonds.

Minisci-type reaction is one of the important means to construct C(sp 3 )-H functionalization of heteroarenes. According to traditional methods, stoichiometric amounts of precious transition metal catalysts and chemical oxidants were required at high temperatures. Here, a green and gentle novel Minisci-type method was developed via visible-light-induced cross-dehydrogenative coupling of heteroarenes with aliphatic C(sp 3 )-H bonds under oxidant-free and transition-metal-catalyst-free conditions. Only the catalytic equivalent of CF 3 SO 2 Na and room temperature were required to maintain an efficient reaction.