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Osteopontin Promotes Macrophage M1 Polarization by Activation of the JAK1/STAT1/HMGB1 Signaling Pathway in Nonalcoholic Fatty Liver Disease.

Zhihao XuFeiyang XiXinxin DengYuqi NiChangqin PuDan WangWeiming LouXufang ZengNing SuChen ChenZiqiang ZengLibin DengMeixiu Jiang
Published in: Journal of clinical and translational hepatology (2022)
OPN promoted macrophage M1 polarization by increasing JAK1/STAT1-induced HMGB1 secretion in hepatocytes.
Keyphrases
  • signaling pathway
  • adipose tissue
  • high glucose
  • drug induced
  • diabetic rats
  • liver injury
  • pi k akt
  • epithelial mesenchymal transition
  • induced apoptosis
  • endothelial cells
  • oxidative stress
  • liver fibrosis