Single Cell Transcriptome Analysis of Peripheral Blood Mononuclear Cells in Freshly Isolated versus Stored Blood Samples.
Hui-Qi QuCharlly KaoJames GarifallouFengxiang WangJames SnyderDiana J SlaterCuiping HouMichael E MarchJohn J ConnollyJoseph T GlessnerHakon HakonarsonPublished in: Genes (2023)
Significant transcriptome changes were observed across different PBMC cell types as a factor of time from blood draw to PBMC isolation and as a consequence of blood storage. This should be kept in mind when interpreting experimental results.