Effects of combined helium pre/post-conditioning on the brain and heart in a rat resuscitation model.

C AehlingN C WeberC J ZuurbierB PreckelR GalmbacherK StefanMarkus W HollmannE PoppJ Knapp

Published in: Acta anaesthesiologica Scandinavica (2017)

Treatment with helium reduced apoptosis in our resuscitation model. Differential expression levels of Caveolin-1, Caveolin-3 and Hexokinase II in the heart were found after helium pre- and post-conditioning. No beneficial effects were seen on neurofunctional outcome.

Keyphrases

cardiac arrest
oxidative stress
heart failure
cardiopulmonary resuscitation
atrial fibrillation
cell death
septic shock
white matter
cell proliferation
signaling pathway
combination therapy