Hepatic noradrenergic innervation acts via CREB/CRTC2 to activate gluconeogenesis during cold.

Henrique J N MorganHeitor B P DelfinoAline Z SchavinskiSamuel A MaloneCamille CharoyNatany G ReisAna P AssisNatalia LautherbachWilian A SilveiraLilian C HeckDan GutonAna I DomingosIsis C KettelhutMarc MontminyLuiz C C Navegantes

Published in: Metabolism: clinical and experimental (2024)

Our data demonstrate the importance of the CREB/CRTC2 pathway in mediating effects of hepatic sympathetic inputs on glucose homeostasis, providing new insights into the role of norepinephrine in health and disease.

Keyphrases

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