Lactate Increases Renal Cell Carcinoma Aggressiveness through Sirtuin 1-Dependent Epithelial Mesenchymal Transition Axis Regulation.
Vera Miranda-GonçalvesAna LameirinhasCatarina Macedo-SilvaJoão LoboPaula C DiasVerónica FerreiraRui M HenriqueCarmen JerónimoPublished in: Cells (2020)
In RCC, lactate enhanced aggressiveness and modulated normal kidney cell phenotype, in part through downregulation of SIRT1, unveiling tumor metabolism as a promising therapeutic target.