Melanoma-specific bcl-2 promotes a protumoral M2-like phenotype by tumor-associated macrophages.
Marta Di MartileValentina FariniFrancesca Maria ConsonniDaniela TrisciuoglioMarianna DesideriElisabetta ValentiniSimona D'AguannoMaria Grazia TuponeSimonetta BuglioniCristiana ErcolaniEnzo GalloBruno AmadioIrene TerrenatoMaria Laura FoddaiAntonio SicaDonatella Del BufaloPublished in: Journal for immunotherapy of cancer (2021)
Taken together, our results show that melanoma-specific bcl-2 controls an IL-1β-driven axis of macrophage diversion that establishes tumor microenvironmental conditions favoring melanoma development. Interfering with this pathway might provide novel therapeutic strategies.