Selective and state-dependent activation of TRESK (K2P 18.1) background potassium channel by cloxyquin.

Miklós LengyelAlice DobolyiGábor Á Czirják Péter Enyedi

Published in: British journal of pharmacology (2017)

Cloxyquin activates TRESK by a Ca2+ /calcineurin-independent mechanism. The drug is specific for TRESK within the K2P channel family and useful for studying TRESK currents in native cells. The state-dependent pharmacological profile of this channel should be considered in the development of therapeutics for migraine and other nociceptive disorders.

Keyphrases

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neuropathic pain
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