Proteomic networks of gray and white matter reveal tissue-specific changes in human tauopathy.
Ashlyn G JohnsonEric B DammerJames A WebsterDuc M DuongNicholas T SeyfriedChadwick M HalesPublished in: Annals of clinical and translational neurology (2024)
The dataset is a valuable resource for understanding proteomic changes in human tauopathy gray and white matter. The identification of unique and shared disease-associated changes across gray and white matter emphasizes the utility of examining both tissue types. Future studies of microglial, endothelial, and mitochondrial changes in white matter may provide novel insights into tauopathy-associated changes in human brain.