Systemic and topical administration of spermidine accelerates skin wound healing.
Daisuke ItoHiroyasu ItoTakayasu IdetaAyumu KanbeSoranobu NinomiyaMasahito ShimizuPublished in: Cell communication and signaling : CCS (2021)
These results indicate that treatment with SPD promotes skin wound healing through activation of the uPA/uPAR pathway and induction of the inflammatory response in wound sites. The administration of SPD might contribute to new effective treatments to accelerate skin wound healing. Video Abstract.