Response of Htr3a knockout mice to antidepressant treatment and chronic stress.

Vincent MartinArmance RiffaudTevrasamy MardayCharly BrouillardBernard FrancJean-Pol TassinCaroline Sevoz-CoucheRaymond MongeauLaurence Lanfumey

Published in: British journal of pharmacology (2017)

Taken together, these data show that Htr3a deletion promotes SSRI efficacy and prevents the occurrence of stress-induced deleterious effects, suggesting that the 5-HT3 receptor may represent an interesting target for the treatment of stress-related disorders.

Keyphrases

stress induced
risk assessment
machine learning
big data
bipolar disorder
binding protein