Antibody reactivity with new antigens revealed in multi-transgenic triple knockout pigs may cause early loss of pig kidneys in baboons.

Yuichi AriyoshiKazuhiro TakeuchiThomas PomposelliDilrukshi K Ekanayake-AlperAkira ShimizuLennan BoydErmance EstimeMayu OhtaArsenoi AsfourJ Scott ArnDavid AyaresMarc LorberMegan SykesDavid H Sachs Kazuhiko Yamada

Published in: Xenotransplantation (2020)

These data suggest that neoantigens associated with mTg Tri-KO promote acute xenograft rejection in a pig-to-baboon VT + K XTx model. The screening assays may be useful to select "safe" recipients to receive mTg Tri-KO kidneys.

Keyphrases

liver failure
respiratory failure
electronic health record
high throughput
single cell
dendritic cells
aortic dissection
drug induced
big data
kidney transplantation
intensive care unit
hepatitis b virus
data analysis
immune response
deep learning
artificial intelligence