Characteristics of Placental Histopathology in Women with Uncomplicated Pregnancies Affected by SARS-CoV-2 Infection at the Time of Delivery: A Single-Center Experience.
Laura SarnoMariavittoria LocciCaterina FulgioneFrancesca PerilloAngela Dell'IsolaDalila MantelliCristina SibilloGabriele SacconeGiuseppe Maria MaruottiDaniela TerraccianoGiuseppe BifulcoMaurizio GuidaMaria D'ArmientoPublished in: Biomedicines (2022)
The aim of this study was, firstly, to analyze the histopathological characteristics of placentas in women with uneventful pregnancies and affected by COVID-19 at the time of delivery; and secondly, to correlate histological findings to maternal and neonatal characteristics. In our single-center prospective observational study, 46 placentas from term uncomplicated singleton pregnancies of patients with a documented SARS-CoV-2 infection at the time of delivery underwent histological examination. Despite a normal feto-maternal outcome, most of the placentas (82.6%) presented signs of maternal vascular malperfusion, while features of fetal vascular malperfusion were found in 54% of cases. No correlation was detected between maternal and neonatal characteristics and the severity of blood circulation disease, and abnormal findings were also described in asymptomatic patients. Moreover, we did not find any maternal symptoms or clinical details allowing for the prediction of abnormal placental findings in pregnancy complicated by COVID-19 infection. Our results suggest that SARS-CoV-2 infection during pregnancy could lead to acute placental dysfunction.
Keyphrases
- pregnancy outcomes
- birth weight
- gestational age
- preterm birth
- pregnant women
- respiratory syndrome coronavirus
- sars cov
- coronavirus disease
- aortic dissection
- end stage renal disease
- weight gain
- preterm infants
- ejection fraction
- chronic kidney disease
- newly diagnosed
- prognostic factors
- oxidative stress
- intensive care unit
- hepatitis b virus
- sleep quality