Prefolded Synthetic G-Quartets Display Enhanced Bioinspired Properties.

Theodore FlackThibaut ConstantinSylvain PenasseJérôme DejeuBéatrice GennaroMuriel JourdanAurélien LaguerreMarc PirrottaDavid Monchaud Nicolas Spinelli Eric Defrancq

Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2015)

A water-soluble template-assembled synthetic G-quartet (TASQ) based on the use of a macrocyclodecapeptide scaffold was designed to display stable intramolecular folds alone in solution. The preformation of the guanine quartet, demonstrated by NMR and CD investigations, results in enhanced peroxidase-type biocatalytic activities and improved quadruplex-interacting properties. Comparison of its DNAzyme-boosting properties with the ones of previously published TASQ revealed that, nowadays, it is the best DNAzyme-boosting agent.

Keyphrases

water soluble
living cells
high resolution
hydrogen peroxide
single cell
solid state
single molecule
meta analyses