In a nutshell: TTP and pregnancy.
P GounderMarie Anne ScullyPublished in: British journal of haematology (2024)
Acute thrombocytopenic purpura (TTP) may present at any stage of pregnancy and the puerperium. Without prompt diagnosis and therapy, serious maternal and fetal outcomes may result. ADAMTS13 replacement via plasma exchange and immunosuppression are the mainstay of treatment. There may be a role, however, for newer therapies, including caplacizumab and recombinant ADAMTS13. Differentiation of immune TTP and congenital TTP is vital, particularly to guide the management of subsequent pregnancies.
Keyphrases
- pregnancy outcomes
- preterm birth
- pregnant women
- liver failure
- gestational age
- birth weight
- type diabetes
- stem cells
- drug induced
- respiratory failure
- mesenchymal stem cells
- skeletal muscle
- metabolic syndrome
- adipose tissue
- bone marrow
- intensive care unit
- physical activity
- hepatitis b virus
- aortic dissection
- mechanical ventilation
- insulin resistance
- extracorporeal membrane oxygenation
- glycemic control