MSC-Derived Extracellular Vesicles Activate Mitophagy to Alleviate Renal Ischemia/Reperfusion Injury via the miR-223-3p/NLRP3 Axis.

Ze-Jia Sun Zihao Gao Ji-Yue Wu Xiang Zheng Shizhao Jing Wei Wang

Published in: Stem cells international (2022)

In conclusion, the protective role of BMSC-derived EVs and exosome-delivered miR-223-3p in RIRI was validated. Exogenous miR-223-3p directly targeted NLRP3 to attenuate inflammasome activation, thereby promoting mitophagy.

Keyphrases

nlrp inflammasome
ischemia reperfusion injury
oxidative stress
cancer therapy
drug delivery