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MSC-Derived Extracellular Vesicles Activate Mitophagy to Alleviate Renal Ischemia/Reperfusion Injury via the miR-223-3p/NLRP3 Axis.

Ze-Jia SunZihao GaoJi-Yue WuXiang ZhengShizhao JingWei Wang
Published in: Stem cells international (2022)
In conclusion, the protective role of BMSC-derived EVs and exosome-delivered miR-223-3p in RIRI was validated. Exogenous miR-223-3p directly targeted NLRP3 to attenuate inflammasome activation, thereby promoting mitophagy.
Keyphrases
  • nlrp inflammasome
  • ischemia reperfusion injury
  • oxidative stress
  • cancer therapy
  • drug delivery