Hyperpolarized 13C-pyruvate MRI detects real-time metabolic flux in prostate cancer metastases to bone and liver: a clinical feasibility study.
Hsin-Yu ChenRahul AggarwalRobert A BokMichael A OhligerZi ZhuPhilip LeeJeremy W GordonMark van CriekingeLucas CarvajalJames B SlaterPeder Eric Zufall LarsonEric J SmallJohn KurhanewiczDaniel B VigneronPublished in: Prostate cancer and prostatic diseases (2019)
HP 13C-pyruvate MRI can detect real-time glycolytic metabolism within prostate cancer metastases, and can measure changes in quantitative kPL values following treatment response at early time points. This first feasibility study supports future clinical studies of HP 13C-pyruvate MRI in the setting of advanced prostate cancer.