Plasma Cell-Free DNA Profiling of PTEN-PI3K-AKT Pathway Aberrations in Metastatic Castration-Resistant Prostate Cancer.

Edmond M Kwan Chao Dai Heidi FettkeChristine HauserMaria M DocantoPatricia BukczynskaNicole NgSiavash ForoughiLisa-Jane K GrahamKate MahonWinston TanXiaohong WangZhixin ZhaoTiantian ZhengKemin ZhouJianjun YuPan DuLisa G HorvathShidong JiaManish Kohli Arun A Azad

Published in: JCO precision oncology (2021)

PTEN-PI3K-AKT pathway CNVs were readily detected using our cfDNA assay, with the prevalence of PTEN loss comparable with tissue-based studies. Additional PTEN-PI3K-AKT pathway aberrations were found in one fifth of PTEN-neutral cases. Concurrent CNVs in the PTEN-PI3K-AKT and AR pathways portended poor survival, and identifying this high-risk patient subset for dual AR/Akt inhibition may optimize precision treatment with Akt inhibitors in mCRPC.

Keyphrases

pi k akt
signaling pathway
cell proliferation
cell cycle arrest
squamous cell carcinoma
small cell lung cancer
copy number
gene expression
risk factors
locally advanced
dna methylation
smoking cessation