As non-renewable cultural heritage, wall paintings play an important role in society. To reveal the trends in the scientific analysis of mural paintings, 845 relevant research articles published from 2011 to 2021 were collected from the Web of Science database and analyzed. The VOSviewer software was adopted to map the network data of scientific publications, so that relationships among authors, countries, institutions can be displayed, and the co-occurrence of keywords and co-citation can be analyzed. The results revealed close and strong interconnections between the top authors, suggesting a considerable strong research link in this field. The cooperation between research institutions was relatively close. The most productive country of relevant publications was Italy. The leading journals for the scientific analysis of wall paintings were Journal of Raman Spectroscopy and Journal of Cultural Heritage . At present, the hotspots of scientific analysis and research on wall painting are revealing the composition, distribution, origin, and deterioration mechanism of pigments, alongside with evaluating the effects and mechanism of conservation materials and techniques. On the one hand, a possible development direction in this field is introducing more cutting-edge analysis and data processing methods. On the other hand, scientific analysis is increasingly adopted to guide the research and development of mural conservation materials.