Proteomic prediction of incident heart failure and its main subtypes.
Valur EmilssonBrynjólfur Gauti Guðrúnar JónssonThomas R AustinValborg GudmundsdottirGisli Thor AxelssonElisabet A FrickThorarinn JonmundssonAnna E SteindorsdottirJoseph J LoureiroJennifer A BrodyThor AspelundLenore J LaunerGudmundur ThorgeirssonKirsten A KortekaasJan H N LindemanAnthony P OrthJohn R LambBruce M PsatyJorge R KizerLori L JenningsVilmundur G GudnasonPublished in: European journal of heart failure (2023)
A small number of circulating proteins accurately predicted future HF in the AGES-RS cohort of older adults, and they alone encompass the risk information found in a collection of clinical data. Incident HF events were predicted up to eight years, with predictor performance significantly improving for events occurring less than one year ahead, a finding replicated in an external cohort study. This article is protected by copyright. All rights reserved.