Fibronectin fragments generated by pancreatic trypsin act as endogenous inhibitors of pancreatic tumor growth.

Andrea ResoviPerla PersichittiLaura BrunelliLucia MinoliPatrizia BorsottiGiulia GarattiniMatteo TironiErica DugnaniMiriam RedegalliGiulia De SimoneRoberta PastorelliMaria Rosa BaniLorenzo PiemontiDeane F MosherRaffaella GiavazziGiulia TarabolettiDorina Belotti

Published in: Journal of experimental & clinical cancer research : CR (2023)

This study identifies a novel role for pancreatic trypsin and fibronectin cleavage as a mechanism of protection against cancer by the pancreatic microenvironment. The finding of a FAK-FGFR cross-talk in PDAC support the combination of FAK and FGFR inhibitors for PDAC treatment to emulate the protective effect of the normal pancreas against cancer.

Keyphrases

papillary thyroid
squamous cell
stem cells
genome wide
squamous cell carcinoma
cell migration
dna methylation
dna binding