Role of Wnt-signaling inhibitors DKK-1 and sclerostin in bone fragility associated with Turner syndrome.

M ChiaritoL PiacenteN ChaoulP PontrelliG D'AmatoA GrandoneG RussoM E StreetM G WasniewskaG BrunettiMaria Felicia Faienza

Published in: Journal of endocrinological investigation (2022)

TS patients showed higher levels of sclerostin and DKK-1 than controls which can be related to HRT, and to reduced bone formation markers as well as the increased bone resorption activity.

Keyphrases

end stage renal disease
bone mineral density
ejection fraction
newly diagnosed
chronic kidney disease
bone loss
peritoneal dialysis
soft tissue
prognostic factors