HoxC6 Functions as an Oncogene and Isoform HoxC6-2 May Play the Primary Role in Gastric Carcinogenesis.

Jinping LinJiamin HeXingkang HeLan WangMeng XueWei ZhuoJianmin SiKan WangShu-Jie Chen

Published in: Digestive diseases and sciences (2020)

HoxC6 acts as an oncogene in gastric carcinogenesis and might be a promising therapeutic target. Isoform HoxC6-2 plays a primary carcinogenic role in gastric carcinogenesis. HOTAIR, over-expressed in gastric cancer, might regulate HoxC6 on the protein level in promoting migration of gastric cells.

Keyphrases

induced apoptosis
oxidative stress
cell cycle arrest
signaling pathway
binding protein