Comparison of linkage disequilibrium estimated from genotypes versus haplotypes for crossbred populations.

Setegn Worku AlemuPiter BijmaMario P L CalusHuiming LiuRohan L FernandoJack C M Dekkers

Published in: Genetics, selection, evolution : GSE (2022)

Our theoretical derivations showed that estimates of LD between loci based on unphased genotypes and haplotypes in F1 crossbreds have identical expectations. Based on our simulation results, we conclude that the LD for an F1 crossbred population can be accurately estimated from unphased genotype data. The results also apply for other crosses (F2, F3, Fn, BC1, BC2, and BCn), as long as (selected) individuals from the two parental lines mate randomly.

Keyphrases

genome wide
electronic health record
big data
dna methylation
genome wide association study
virtual reality
gene expression
hepatitis c virus
deep learning
human immunodeficiency virus
artificial intelligence
clinical evaluation
high density