Tenecteplase Treatment and Thrombus Characteristics Associated With Early Reperfusion: An EXTEND-IA TNK Trials Analysis.
Vignan YogendrakumarLeonid ChurilovProdipta GuhaJames BeharryPeter J MitchellTimothy John KleinigNawaf YassiVincent N ThijsTeddy Y WuHelen BrownHelen M DeweyTissa WijeratneBernard YanGagan SharmaPatricia M DesmondMark W ParsonsGeoffrey Alan DonnanStephen M DavisBruce C V Campbellnull nullPublished in: Stroke (2023)
Tenecteplase demonstrates superior early reperfusion versus alteplase in lesions with low clot burden. Reperfusion efficacy remains limited in internal carotid artery occlusions and lesions with high clot burden. Further innovation in thrombolytic therapies are required.