Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells.
Jang Hee HanYong Keon KimHakhyun KimJooyoung LeeMyung Joon OhSang Bum KimMinjee KimKook Hwan KimHyun Ju YoonMyung-Shik LeeJohn D MinnaMichael A WhiteHyun Seok KimPublished in: Cancer communications (London, England) (2022)
This study demonstrates that autophagy-derived acetyl-CoA promotes Snail acetylation and thereby facilitates invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells and that inhibition of the autophagy/acetyl-CoA/acetyl-Snail axis using CAMKK2 or ACLY inhibitors could be a potential therapeutic strategy to suppress metastasis of KL lung cancer.