Relative oxygen extraction fraction (rOEF) MR imaging reveals higher hypoxia in human epidermal growth factor receptor (EGFR) amplified compared with non-amplified gliomas.

Talia C OughourlianJingwen YaoAkifumi HagiwaraDavid A NathansonCatalina RaymondWhitney B PopeNoriko SalamonAlbert LaiMatthew JiPhioanh L NghiemphuLinda M LiauTimothy F CloughesyBenjamin M Ellingson

Published in: Neuroradiology (2020)

Imaging of tumor oxygen characteristics revealed EGFR-amplified gliomas to be more hypoxic and contribute to shorter patient survival than EGFR non-amplified gliomas.

Keyphrases

epidermal growth factor receptor
tyrosine kinase
high grade
advanced non small cell lung cancer
endothelial cells
small cell lung cancer
high resolution
case report
magnetic resonance imaging
single cell
mass spectrometry