Single-Nucleus Chromatin Accessibility Identifies a Critical Role for TWIST1 in IPF Myofibroblast Activity.
Eleanor ValenziHarinath BahudhanapatiJiangning TanTracy TabibDaniel I SullivanSeyed Mehdi NouraieJohn SembratLi FanKong ChenSilvia LiuMauricio RojasAudrey LafargueDean W FelsherPhuoc T TranDaniel J KassRobert A LafyatisPublished in: The European respiratory journal (2023)
murine disease models confirm a critical regulatory function for TWIST1 in IPF myofibroblast activity in the fibrotic lung. Understanding the global process of opening TWIST1 and other E-box TF motifs that govern myofibroblast differentiation may identify new therapeutic interventions for fibrotic pulmonary diseases.