Low-level HIV-1 viremia affects T-cell activation and senescence in long-term treated adults in the INSTI era.
Violeta Lara-AguilarManuel Llamas-AdánÓscar Brochado-KithCelia Crespo-BermejoSergio Grande-GarcíaSonia Arca-LafuenteIgnacio de Los SantosCarmen PradoMario AlíaCoral Sainz-PinósAmanda Fernández-RodríguezLuz Martín-CarboneroRicardo MadridVerónica BrizPublished in: Journal of biomedical science (2024)
LLV between 50 and 200 copies/mL leads to reduced cytotoxic activity and T-cell dysfunction that could affect cytokine production, being unable to control and eliminate infected cells. The increase in senescence markers suggests a progressive loss of immunological memory and a reduction in the proliferative capacity of immune cells. This accelerated immune aging could lead to an increased risk of developing future comorbidities. These findings strongly advocate for heightened surveillance of these PWH to promptly identify potential future complications.
Keyphrases
- cell proliferation
- current status
- induced apoptosis
- dna damage
- endothelial cells
- antiretroviral therapy
- hiv positive
- hiv infected
- human immunodeficiency virus
- cell cycle arrest
- multiple sclerosis
- oxidative stress
- public health
- stress induced
- hepatitis c virus
- hiv testing
- hiv aids
- risk factors
- endoplasmic reticulum stress
- risk assessment
- climate change
- newly diagnosed