Identification of mutant K-RAS in pituitary macroadenoma.

Veronica AranManoela HeringerPaulo Jose da MataLeandro KasukiRenan Lyra MirandaFelipe AndreiuoloLeila ChimelliPaulo Niemeyer FilhoMonica Roberto GadelhaVivaldo Moura Neto

Published in: Pituitary (2021)

Our findings highlight the exceptional capacity of the digital PCR in detecting low frequency mutations (below 1%), since we detected, for the first time, K-RAS mutations in pituitary macroadenoma. The potential impact of K-RAS mutations in these tumours should be further investigated.

Keyphrases

wild type
growth hormone
risk assessment
mass spectrometry
bioinformatics analysis