Upregulation of IL-6 expression in human salivary gland cell line by IL-17 via activation of p38 MAPK, ERK, PI3K/Akt, and NF-κB pathways.

Lili WeiHaofei XiongWei LiBo LiYong Cheng

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2018)

The HSG cells expressed IL-17R and reacted to IL-17 to generate IL-6 via the stimulation of ERK, p38 MAPK, Akt, and NF-κB signaling pathways.

Keyphrases

signaling pathway
pi k akt
induced apoptosis
cell cycle arrest
cell proliferation
epithelial mesenchymal transition
cell death
endoplasmic reticulum stress
binding protein