Au-siRNA@ aptamer nanocages as a high-efficiency drug and gene delivery system for targeted lung cancer therapy.
Yuming YangYu HanQiuyang SunJin ChengCaixia YueYanlei LiuJie SongWeilin JinXianting DingJesús M de la FuenteJian NiXiaoqiang WangDa-Xiang CuiPublished in: Journal of nanobiotechnology (2021)
The development of nanocarriers with double-stranded DNA and MMP-2 cleavable peptides provides a new strategy for the combined delivery of gene and chemotherapy medicine. Au-siRNA-PAA-AS1411 exerts high anticancer activities on lung cancer, indicating immense potentials for clinical application.
Keyphrases
- cancer therapy
- high efficiency
- drug delivery
- sensitive detection
- copy number
- genome wide
- genome wide identification
- gold nanoparticles
- reduced graphene oxide
- circulating tumor
- cell free
- emergency department
- binding protein
- squamous cell carcinoma
- cell migration
- genome wide analysis
- amino acid
- rectal cancer
- drug induced
- chemotherapy induced