Metformin and combined oral contraceptive pills in the management of polycystic ovary syndrome: a systematic review and meta-analysis.
Johanna M MelinMaria ForslundSimon AlesiAnnemieke HoekDaniela RomualdiPoli Mara SpritzerChau Thien TayAlexia PenaSelma Feldman WitchelAya MousaHelena TeedePublished in: The Journal of clinical endocrinology and metabolism (2023)
The choice of metformin or COCP treatment should be based on symptoms, noting that there are some biochemical benefits from combination treatment, targeting both major endocrine disturbances seen in PCOS; hyperinsulinemia and hyperandrogenism.