Terpenoids from the Liverwort Plagiochila fruticosa and Their Antivirulence Activity against Candida albicans.
Ya-Nan QiaoXue-Yang JinJin-Chuan ZhouJiao-Zhen ZhangWen-Qiang ChangYi LiWang ChenZhao-Jie RenChun-Yang ZhangShuang-Zhi YuanHong-Xiang LouPublished in: Journal of natural products (2020)
Fourteen new terpenoids plagicosins A-N (1-14), including seven sesquiterpenoids (1-7) consisting of six ent-bicyclogermacrenes and one ent-2,3-seco-aromadendrane, as well as seven diterpenoids (8-14) comprising five fusicoccanes, a eunicellane, and a rare gersemiane, were isolated from the Chinese liverwort Plagiochila fruticosa Mitt. The structures of these terpenoids were determined on the basis of comprehensive analysis of MS and NMR spectroscopic data coupled with electronic circular dichroism (ECD) and coupling constant calculations. Plagicosin F (6) displayed potent antivirulence activity through inhibiting the hyphal morphogenesis, adhesion, and biofilm formation of Candida albicans. The genes related to hyphal formation were regulated by 6.
Keyphrases
- candida albicans
- biofilm formation
- high resolution
- mass spectrometry
- multiple sclerosis
- magnetic resonance
- molecular docking
- electronic health record
- genome wide
- signaling pathway
- density functional theory
- big data
- molecular dynamics
- cystic fibrosis
- pseudomonas aeruginosa
- transcription factor
- ionic liquid
- genome wide identification
- data analysis