Platinum-based chemotherapy induces opposing effects on immunotherapy response-related spatial and stromal biomarkers in the bladder cancer microenvironment.
Maksim A ChelushkinJeroen van DorpSandra van WilpeIris M SeignetteJan-Jaap J MellemaMaartje AlkemadeAlberto Gil-JimenezDennis PetersWim BrugmanChantal F StockemErik HooijbergAnnegien BroeksBas W G van RhijnLaura S MertensAntoine G Van der HeijdenNiven MehraMaurits L van MontfoortLodewyk F A WesselsDaniel J VisMichiel S Van Der HeijdenPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
The opposing effects of platinum-based chemotherapy on the immune cell composition and stromal context of the tumor-immune microenvironment may explain the inconsistent results of clinical trials investigating chemotherapy and immune checkpoint inhibitor combinations in bladder cancer.