The effects of CD148 Q276P/R326Q polymorphisms in A431D epidermoid cancer cell proliferation and epidermal growth factor receptor signaling.

Lilly HeKeiko TakahashiLejla PasicChikage NaruiPhilipp EllingerManuel GrundmannTakamune Takahashi

Published in: Cancer reports (Hoboken, N.J.) (2021)

Our data demonstrates that Q276P/R326Q mutations do not have major effects on TSP1-CD148 interaction as well as on CD148's cellular localization and activity to inhibit EGFR signaling and cell proliferation.

Keyphrases

growth factor
cell proliferation
small cell lung cancer
epidermal growth factor receptor
squamous cell carcinoma
pi k akt
electronic health record
tyrosine kinase
big data
lymph node metastasis
artificial intelligence