GH/IGF-1 axis in a large cohort of ß-thalassemia major adult patients: a cross-sectional study.

Irene GagliardiR MungariM R GamberiniM FortiniFrancesca DassieM C PuttiP MaffeiLudovica Aliberti Marta Bondanelli Maria Chiara Zatelli Maria Rosaria Ambrosio

Published in: Journal of endocrinological investigation (2022)

GHD is frequent in adult ßTM patients and is associated with higher BMI and worse lipid profile. nGHD patients present lower IGF-1 levels as well. There was no relationship between IGF-1 levels and liver disease. Further, multicentric studies with larger cohorts and standardized diagnostic protocols are needed.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
peritoneal dialysis
body mass index
binding protein
physical activity
patient reported outcomes
risk factors
growth hormone
pi k akt
cell proliferation