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Impact of immune-related adverse events on the therapeutic efficacy of pembrolizumab in urothelial carcinoma: a multicenter retrospective study using time-dependent analysis.

Taketo KawaiSatoru TaguchiTohru NakagawaJun KameiYu NakamuraDaisuke ObinataKenya YamaguchiTomoyuki KanekoShigenori KakutaniMayuko TokunagaYukari UemuraYusuke SatoYutaka EnomotoHiroaki NishimatsuTetsuya FujimuraHiroshi FukuharaSatoru TakahashiHaruki Kume
Published in: Journal for immunotherapy of cancer (2022)
Even after minimizing immortal time bias by time-dependent analysis, the incidence of irAEs, especially grade 1-2 irAEs, could be a significant predictor of favorable prognoses in patients with UC who have undergone pembrolizumab treatment.
Keyphrases
  • advanced non small cell lung cancer
  • clinical trial
  • risk factors