The Relationship between Mood and Anxiety and Cognitive Phenotypes in Adults with Pharmacoresistant Temporal Lobe Epilepsy.

This study demonstrates that psychiatric factors are not only associated with function in specific cognitive domains but with the pattern and extent of deficits across cognitive domains. Results suggest that depressive symptoms and medications are strongly related to cognitive phenotype in adults with TLE and support the inclusion of these factors as diagnostic modifiers for cognitive phenotypes in future work. Longitudinal studies that incorporate neuroimaging findings are warranted to further our understanding of the complex relationships between cognition, mood, and seizures and to determine whether non-pharmacologic treatment of mood symptoms alters cognitive phenotype.