Sex differences in dementia with Lewy bodies: an imaging study of neurotransmission pathways.

Cecilia BoccaliniNicolas NicastroDebora Elisa PerettiSilvia Paola CaminitiDaniela PeraniValentina Garibotto

Published in: European journal of nuclear medicine and molecular imaging (2023)

I-FP-CIT binding in females, significant in the presence of a pDLB diagnosis. pDLB females showed also different patterns of connectivity compared to males, mostly involving extrastriatal regions. The results suggest the presence of a sex-related regional vulnerability to alpha-synuclein pathology, possibly complicated also by the higher prevalence of Alzheimer's disease co-pathology in females, as previously reported in pDLB populations.

Keyphrases

mild cognitive impairment
high resolution
climate change
risk factors
cognitive decline
parkinson disease
resting state
functional connectivity
mass spectrometry
binding protein
photodynamic therapy