Cathepsin L-induced galectin-1 may act as a proangiogenic factor in the metastasis of high-grade serous carcinoma.
Md Zahidul I PranjolDmitry A ZinovkinAnnelie R T MaskellLaura J StephensSergey L AchinovichDmitry M Los'Eldar A NadyrovMichael HannemannNicholas J GutowskiJacqueline L WhatmorePublished in: Journal of translational medicine (2019)
HOMEC Gal1 transcription and release in response to CathL secreted from metastasising HGSC acts in an autocrine manner on the local microvasculature to induce pro-angiogenic changes, highlighting a potential new therapeutic target.