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Cathepsin L-induced galectin-1 may act as a proangiogenic factor in the metastasis of high-grade serous carcinoma.

Md Zahidul I PranjolDmitry A ZinovkinAnnelie R T MaskellLaura J StephensSergey L AchinovichDmitry M Los'Eldar A NadyrovMichael HannemannNicholas J GutowskiJacqueline L Whatmore
Published in: Journal of translational medicine (2019)
HOMEC Gal1 transcription and release in response to CathL secreted from metastasising HGSC acts in an autocrine manner on the local microvasculature to induce pro-angiogenic changes, highlighting a potential new therapeutic target.
Keyphrases
  • high grade
  • low grade
  • high glucose
  • diabetic rats
  • anti inflammatory
  • drug induced
  • endothelial cells
  • human health
  • oxidative stress
  • risk assessment