Familial aggregation of seizure outcomes in four familial epilepsy cohorts.

Colin A EllisDanni TuKaren L Oliver Heather C MeffordW Allen HauserJeffrey R BuchhalterMichael P EpsteinQuy Caonull nullnull nullSamuel Frank Berkovic Ruth Ottman

Published in: Epilepsia (2024)

A history of ≥4 tonic-clonic seizures aggregated strongly in families, suggesting a genetic influence, whereas seizure remission and seizure control for individuals taking antiseizure medications did not aggregate consistently in families. Different seizure outcomes may have different underlying biology and risk factors. These findings should inform the future molecular genetic studies of seizure outcomes.

Keyphrases

temporal lobe epilepsy
risk factors
type diabetes
metabolic syndrome
copy number
adipose tissue
glycemic control
insulin resistance
weight loss