No Cell Left Unturned: Intraductal Papillary Mucinous Neoplasm Heterogeneity.

Yasmin G Hernandez-BarcoNabeel BardeesyDavid Tsai Ting

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Intraductal papillary mucinous neoplasm (IPMN) is a pancreatic cancer precursor lesion with established genetic features, but the cellular ecosystem of these tumors remains to be fully characterized. This study utilizes single-cell RNA sequencing to describe the dynamic landscape of epithelial, immune, and stromal cells during IPMN progression to invasive cancer.See related article by Bernard et al., p. 2194.

Keyphrases

single cell
low grade
rna seq
high throughput
high grade
papillary thyroid
climate change
clear cell
squamous cell
gene expression
stem cells
copy number
young adults