Citrus unshiu Peel Attenuates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice due to Modulation of the PI3K/Akt Signaling Pathway and MAPK and NF- κ B.
Se Hui LeeJin A LeeMi-Rae ShinHae-Jin ParkSeong-Soo RohPublished in: Evidence-based complementary and alternative medicine : eCAM (2022)
These results show that CUP not only suppresses oxidative stress in UC but also regulates inflammation-related proteins and apoptotic proteins by regulating the PI3K/Akt signaling pathway, suggesting that it has the potential as a material for developing new natural therapeutic agents for UC.
Keyphrases
- signaling pathway
- oxidative stress
- diabetic rats
- pi k akt
- induced apoptosis
- ulcerative colitis
- epithelial mesenchymal transition
- cell death
- high glucose
- dna damage
- ischemia reperfusion injury
- drug induced
- high fat diet induced
- inflammatory response
- adipose tissue
- risk assessment
- human health
- metabolic syndrome
- heat shock
- climate change
- lps induced
- stress induced