A new 30-norfriedelane triterpnoid from Caloncoba lophocarpa (Oliv.) Gilg. (Achariaceae).

The chemical investigation of the methanol extract of the roots of Caloncoba lophocarpa (Oliv.) Gilg. exhibited a new 30-norfriedelane triterpenoid, laphocarpanol ( 1 ), together with seven known compounds, caloncobalactone ( 2 ), friedelin ( 3 ), friedelanol (4 ), asperphernamate ( 5 ), stigmasterol ( 6 ), sitosterol ( 7 ) and sitosterol-3- O - β -D-glucopyranoside ( 8 ). The structures of the compounds were elucidated by extensive spectroscopic and spectrometric analyses (1D and 2D NMR, ESI-MS) and by comparison with previously reported data. All the compounds were tested for their antifungal and antibacterial activities. Compound 1 displayed weak antibacterial effect with MIC value of 62.5 μg/mL against Shigella flexineri . All the isolates were found to be inactive against the tested fungal strains.