Role of Complement C5 in Experimental Blunt Chest Trauma-Induced Septic Acute Lung Injury (ALI).

Miriam KalbitzMichael KarbachSonja BraumuellerPhilipp KellermannFlorian GebhardMarkus Huber-LangMario Perl

Published in: PloS one (2016)

In the complex but clinically relevant DH model the local and systemic inflammatory immune response features both, C5-dependent and C5-independent characteristics. Activation of caspase-3 in lung tissue after DH was C5-dependent whereas local inflammation in lung tissue was C5-independent.

Keyphrases

immune response
oxidative stress
trauma patients
lipopolysaccharide induced
cell death
high glucose
lps induced
induced apoptosis
dendritic cells
toll like receptor
inflammatory response
stress induced